The 400GT 2 2 left the factory on Italy in 1967 and was one of only four to be imported into Britain
It was purchased by the Beatles' bassist in February 1968 during the height of the band's fame and joined his considerable collection of sports cars.
The red two-door was converted to right-hand drive especially for the singer and he continued to own it for over a decade, before finally parting with the powerful V12 in 1979.
Since then the Italian classic has had a number of owners and has now emerged for sale once again with Bonhams Auctions in London.
The auctioneers are predicting the coupe, which is one of just 250 to be built, will attract offers of between £400,000 and £500,000.